Chronic meningitis as an initial presentation of Sjögren syndrome

Translated title of the contribution: Chronic meningitis as an initial presentation of Sjögren syndrome

Andrely Huerta-Rosario, Roberto A. Molina, Jésica J. Ventura-Chilón, Aníbal Terreros, Carlos Alva-Diaz, Kevin Pacheco-Barrios, Roberto Romero Sánchez, Nicanor Mori Quispe

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Sjögren syndrome (SS) is an autoimmune disease, rarely affecting the central nervous system. The case is reported on a 68-year-old male patient who presented with keratoconjunctivitis sicca and xerostomia, during neuropsychological evaluation showed moderate to severe multidomain cognitive impairment. The magnetic resonance showed evidence of hypertrophic pachymeningitis. The CSF study showed pleocytosis, mild proteinuria, and negative cultures. The immune positive profile, Anti SS-A, SS-B and salivary gland biopsy was compatible with SS. The treatment was started with methylprednisolone pulses at a dose of 1 g every 24 h for three days, and controlled with maintenance therapy, showing a favorable response. Chronic meningitis is a diagnostic challenge; among the less common causes is hypertrophic pachymeningitis in SS, and less frequently in male patients (1/9). Non-specific neurological manifestations should be considered, such as headaches or neuropsychiatric symptoms, as on some occasions rare cases may be encountered, such as the one described.

Translated title of the contributionChronic meningitis as an initial presentation of Sjögren syndrome
Original languageEnglish
Pages (from-to)166-170
Number of pages5
JournalRevista Colombiana de Reumatologia
StatePublished - Oct 2020


  • Hypertrophic pachymeningitis
  • Meningitis
  • Sjögren's syndrome


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