TY - JOUR
T1 - Increase in quinolone resistance in a Haemophilus influenzae strain isolated from a patient with recurrent respiratory infections treated with ofloxacin
AU - Vila, Jordi
AU - Ruiz, Joaquim
AU - Sanchez, Ferran
AU - Navarro, Ferran
AU - Mirelis, Beatriz
AU - Jimenez De Anta, M. Teresa
AU - Prats, Guillem
PY - 1999
Y1 - 1999
N2 - The increase in the level of quinolone resistance of Haemophilus influenzae clinical isolates during ofloxacin therapy of a patient with recurrent respiratory infections was investigated. The first isolate (MIC of ciprofloxacin of 2 μg/ml) and the second isolate (MIC of 32 μg/ml) belonged to the same clone, as shown by pulsed-field gel electrophoresis, and the increase in the resistance level was associated with a substitution in Ser- 84 to Arg in the Parc protein. These results emphasize the potential risk of development of quinolone-resistant H. influenzae during fluoroquinolone therapy in patients with recurrent respiratory infection.
AB - The increase in the level of quinolone resistance of Haemophilus influenzae clinical isolates during ofloxacin therapy of a patient with recurrent respiratory infections was investigated. The first isolate (MIC of ciprofloxacin of 2 μg/ml) and the second isolate (MIC of 32 μg/ml) belonged to the same clone, as shown by pulsed-field gel electrophoresis, and the increase in the resistance level was associated with a substitution in Ser- 84 to Arg in the Parc protein. These results emphasize the potential risk of development of quinolone-resistant H. influenzae during fluoroquinolone therapy in patients with recurrent respiratory infection.
UR - http://www.scopus.com/inward/record.url?scp=0032959175&partnerID=8YFLogxK
U2 - 10.1128/aac.43.1.161
DO - 10.1128/aac.43.1.161
M3 - Artículo
C2 - 9869583
AN - SCOPUS:0032959175
SN - 0066-4804
VL - 43
SP - 161
EP - 162
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 1
ER -
