TY - JOUR
T1 - Impact of pathological features of brain metastases in prognosis
AU - Castaneda, Carlos A.
AU - Castillo, Miluska
AU - Bernabe, Luis A.
AU - Sanchez, Joselyn
AU - Casavilca, Sandro
AU - García-Corrochano, Pamela
AU - Ponce, Jaime
AU - Villa-Robles, Maria R.
AU - Lopez, Carolina Belmar
AU - Orrego, Enrique
N1 - Publisher Copyright:
© 2018 2018 Future Medicine Ltd.
PY - 2018/5
Y1 - 2018/5
N2 - Aim: To evaluate the prognostic value of tumor-infiltrating lymphocytes (TILs) and Ki67 in brain metastasis lesions, and the effect of adding them to variables of graded prognostic assessment score. Patients & methods: Clinicopathological information from 111 medical charts of brain metastasis patients was obtained, and TIL distribution (n = 84), Ki67 index (n = 79) and CD3 TIL (n = 64) were prospectively evaluated. Results: Most frequent TIL pattern was perivascular (67.8%), and median Ki67 and CD3 TIL percents were 30 and 4.8%, respectively. Ki67 ≥15 was associated with shorter survival (p = 0.018) but CD3 TIL was not (p = 0.870). The highest graded prognostic assessment score was not associated with survival (p = 0.648), however, those with low Ki67 and high score was associated with better outcome (p = 0.007). Conclusion: High Ki67 index in brain metastasis carries a worse prognosis.
AB - Aim: To evaluate the prognostic value of tumor-infiltrating lymphocytes (TILs) and Ki67 in brain metastasis lesions, and the effect of adding them to variables of graded prognostic assessment score. Patients & methods: Clinicopathological information from 111 medical charts of brain metastasis patients was obtained, and TIL distribution (n = 84), Ki67 index (n = 79) and CD3 TIL (n = 64) were prospectively evaluated. Results: Most frequent TIL pattern was perivascular (67.8%), and median Ki67 and CD3 TIL percents were 30 and 4.8%, respectively. Ki67 ≥15 was associated with shorter survival (p = 0.018) but CD3 TIL was not (p = 0.870). The highest graded prognostic assessment score was not associated with survival (p = 0.648), however, those with low Ki67 and high score was associated with better outcome (p = 0.007). Conclusion: High Ki67 index in brain metastasis carries a worse prognosis.
KW - brain metastasis
KW - infiltrating lymphocytes
KW - proliferation index
KW - survival
UR - http://www.scopus.com/inward/record.url?scp=85046846243&partnerID=8YFLogxK
U2 - 10.2217/bmm-2017-0161
DO - 10.2217/bmm-2017-0161
M3 - Artículo
C2 - 29697273
AN - SCOPUS:85046846243
SN - 1752-0363
VL - 12
SP - 475
EP - 485
JO - Biomarkers in Medicine
JF - Biomarkers in Medicine
IS - 5
ER -