Immune reconstitution syndrome due to BCG in HIV-treated children

Translated title of the contribution: Immune reconstitution syndrome due to BCG in HIV-treated children

Edwin Miranda-Choque, Jorge Candela-Herrera, Eddy R. Segura, Sonia Farfán-Ramos, Aldo Barriga

Research output: Contribution to journalArticlepeer-review


The objective of this study is to describe the clinical profile of the immune reconstitution syndrome due to Mycobacterium bovis Bacillus Calmette-Guérin (IRS-BCG) in children with HIV infection who receive highly active antiretroviral treatment (HAART) at Instituto Nacional de Salud del Niño de Lima (National Children's Health Institute of Lima), Peru. A case study was conducted, including 8 children with IRS-BCG, defined as the presence of regional lymphadenopathy or inflammation on the BCG vaccination site with at least one less logarithm in the viral load or immune improvement. All patients had AIDS (C3). The starting median age in HAART was 7.2 months and the event occurred 3 to 11 weeks after the treatment was started. 7 cases showed axillary adenitis. When compared with the Non IRS-BCG group, a significant association between the age at which HAART was started at one year, severe immunodepression, and increased viral load was found. It is concluded that IRS-BCG was related to a rapid clinical progression of the mother-to-child transmitted HIV/AIDS infection, severe immunosuppression and high viral load when the HAART began.

Translated title of the contributionImmune reconstitution syndrome due to BCG in HIV-treated children
Original languageEnglish
Pages (from-to)498-502
Number of pages5
JournalRevista Peruana de Medicina Experimental y Salud Publica
Issue number4
StatePublished - 2012
Externally publishedYes


  • Antiretroviral therapy
  • BCG
  • Child
  • HIV
  • Highly active
  • Immunology


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