High rates of extensively drug-resistant Acinetobacter baumannii in a Peruvian hospital 2013–2019

Rodrigo Samuel Barrientos-Yong; Bryan Andrei Hinojosa-Salas; Percy Genaro Salas-Ponce; Eddie Angles; Joaquim Ruiz; Maria J. Pons

doi:10.1177/00494755221142939

High rates of extensively drug-resistant Acinetobacter baumannii in a Peruvian hospital 2013–2019

Rodrigo Samuel Barrientos-Yong, Bryan Andrei Hinojosa-Salas, Percy Genaro Salas-Ponce, Eddie Angles, Joaquim Ruiz, Maria J. Pons

Medicina humana

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Multidrug-resistant (MDR) Acinetobacter baumannii has become a major concern of hospital care. The objective of the study was to evaluate the evolution of antimicrobial resistance of A. baumannii in a Peruvian hospital from 2013 to 2019. A total of 993 A. baumannii clinical isolates were recovered. Antimicrobial resistance levels were extremely high, except for colistin. Among the remaining antibacterial agents, ampicillin plus sulbactam (AMS) was the most active (71.4% of resistance), with resistance levels to the remaining agents ranging from 75.9% to amikacin to 99.2% to ertapenem. The presence of significant differences was observed in extensively drug-resistant (XDR) A. baumannii according to samples origin. No association was observed between MDR or XDR isolates and seasonality. An impressive rate of XDR A. baumannii isolates was found, including a growing number of only-colistin-susceptible isolates highlighting the urgent need for new therapeutic alternatives.

Original language	English
Pages (from-to)	248-255
Number of pages	8
Journal	Tropical Doctor
Volume	53
Issue number	2
DOIs	https://doi.org/10.1177/00494755221142939
State	Published - Apr 2023

Keywords

Acinetobacter baumannii
Latin America
Multidrug-resistant
extensively drug-resistant

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "High rates of extensively drug-resistant Acinetobacter baumannii in a Peruvian hospital 2013–2019",

abstract = "Multidrug-resistant (MDR) Acinetobacter baumannii has become a major concern of hospital care. The objective of the study was to evaluate the evolution of antimicrobial resistance of A. baumannii in a Peruvian hospital from 2013 to 2019. A total of 993 A. baumannii clinical isolates were recovered. Antimicrobial resistance levels were extremely high, except for colistin. Among the remaining antibacterial agents, ampicillin plus sulbactam (AMS) was the most active (71.4% of resistance), with resistance levels to the remaining agents ranging from 75.9% to amikacin to 99.2% to ertapenem. The presence of significant differences was observed in extensively drug-resistant (XDR) A. baumannii according to samples origin. No association was observed between MDR or XDR isolates and seasonality. An impressive rate of XDR A. baumannii isolates was found, including a growing number of only-colistin-susceptible isolates highlighting the urgent need for new therapeutic alternatives.",

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AU - Barrientos-Yong, Rodrigo Samuel

AU - Hinojosa-Salas, Bryan Andrei

AU - Salas-Ponce, Percy Genaro

AU - Angles, Eddie

AU - Ruiz, Joaquim

AU - Pons, Maria J.

N1 - Publisher Copyright: © The Author(s) 2022.

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N2 - Multidrug-resistant (MDR) Acinetobacter baumannii has become a major concern of hospital care. The objective of the study was to evaluate the evolution of antimicrobial resistance of A. baumannii in a Peruvian hospital from 2013 to 2019. A total of 993 A. baumannii clinical isolates were recovered. Antimicrobial resistance levels were extremely high, except for colistin. Among the remaining antibacterial agents, ampicillin plus sulbactam (AMS) was the most active (71.4% of resistance), with resistance levels to the remaining agents ranging from 75.9% to amikacin to 99.2% to ertapenem. The presence of significant differences was observed in extensively drug-resistant (XDR) A. baumannii according to samples origin. No association was observed between MDR or XDR isolates and seasonality. An impressive rate of XDR A. baumannii isolates was found, including a growing number of only-colistin-susceptible isolates highlighting the urgent need for new therapeutic alternatives.

AB - Multidrug-resistant (MDR) Acinetobacter baumannii has become a major concern of hospital care. The objective of the study was to evaluate the evolution of antimicrobial resistance of A. baumannii in a Peruvian hospital from 2013 to 2019. A total of 993 A. baumannii clinical isolates were recovered. Antimicrobial resistance levels were extremely high, except for colistin. Among the remaining antibacterial agents, ampicillin plus sulbactam (AMS) was the most active (71.4% of resistance), with resistance levels to the remaining agents ranging from 75.9% to amikacin to 99.2% to ertapenem. The presence of significant differences was observed in extensively drug-resistant (XDR) A. baumannii according to samples origin. No association was observed between MDR or XDR isolates and seasonality. An impressive rate of XDR A. baumannii isolates was found, including a growing number of only-colistin-susceptible isolates highlighting the urgent need for new therapeutic alternatives.

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KW - Multidrug-resistant

KW - extensively drug-resistant

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High rates of extensively drug-resistant Acinetobacter baumannii in a Peruvian hospital 2013–2019

Abstract

Keywords

UN SDGs

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