High mortality among hospitalized adult patients with COVID-19 pneumonia in Peru: A single centre retrospective cohort study

Guiliana Mas-Ubillus, Pedro J. Ortiz, Jorge Huaringa-Marcelo, Paola Sarzo-Miranda, Patricia Muñoz-Aguirre, Alejandra Diaz-Ramos, Kattia Arribasplata-Purizaca, Doris Mendoza, Juan Rojas-Poma, Cristian Marcelo-Ruiz, Pedro Ayala-Diaz, Edwin Hidalgo-Arroyo, Lourdes Tupia-Cespedes

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Abstract

Background Peru is the country with the world's highest COVID-19 death rate per capita. Characteristics associated with increased mortality among adult patients with COVID-19 pneumonia in this setting are not well described. Methods Retrospective, single-center cohort study including 1537 adult patients hospitalized with a diagnosis of SARS-CoV-2 pneumonia between May 2020 and August 2020 at a national hospital in Lima, Peru. The primary outcome measure was in-hospital mortality. Results In-hospital mortality was 49.71%. The mean age was 60 ± 14.25 years, and 68.38% were males. We found an association between mortality and inflammatory markers, mainly leukocytes, D-dimer, lactate dehydrogenase, C-reactive protein and ferritin. A multivariate model adjusted for age, hypertension, diabetes mellitus, and corticosteroid use demonstrated that in-hospital mortality was associated with greater age (RR: 2.01, 95%CI: 1.59-2.52) and a higher level of oxygen requirement (RR: 2.77, 95%CI: 2.13-3.62). Conclusions: In-hospital mortality among COVID-19 patients in Peru is high and is associated with greater age and higher oxygen requirements.

Original languageEnglish
Article numbere0265089
JournalPLoS ONE
Volume17
Issue number3 March 2022
DOIs
StatePublished - Mar 2022

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