Haematological Alterations Associated with Selected Vector-Borne Infections and Exposure in Dogs from Pereira, Risaralda, Colombia

D. Katterine Bonilla-Aldana, Erwin J. Gutiérrez-Grajales, Daniela Osorio-Navia, Mariana Chacón-Peña, Adrián E. Trejos-Mendoza, Soffia Pérez-Vargas, Lorenzo Valencia-Mejía, Luisa F. Marín-Arboleda, J. Paola Martínez-Hidalgo, María Angelica Reina-Mora, Luz Victoria González-Colonia, Jaime A. Cardona-Ospina, Erika Vanessa Jiménez-Posada, Diego Andrés Diaz-Guio, Jean Carlos Salazar, Manuel Sierra, Fausto Muñoz-Lara, Lysien I. Zambrano, Eduardo Ramírez-Vallejo, Juan Camilo ÁlvarezIngrid Lorena Jaramillo-Delgado, Samuel Pecho-Silva, Alberto Paniz-Mondolfi, Álvaro A. Faccini-Martínez, Alfonso J. Rodríguez-Morales

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Infections due to Ehrlichia, Anaplasma, Dirofilaria, Mycoplasma, Babesia and Hepatozoon continue to be highly prevalent in dogs, especially in tropical and subtropical areas, where vectors of many of them are present. However, many clinical aspects of dogs have not been characterized in detail, including assessing the haematological alterations associated with them, particularly in Colombia and Latin America. A group of 100 dogs with Ehrlichia, Anaplasma, Dirofilaria, Mycoplasma, Babesia and Hepatozoon infections/exposure were assessed by blood smear serology (SNAP4DX) and PCR in Pereira, Colombia. We performed blood counts to evaluate anaemia, leukopenia/leukocytosis, neutropenia, neutrophilia, lymphopenia/lymphocytosis, monocytosis, eosinophilia, and thrombocytopenia, among other alterations. Bivariate analyses were performed on Stata®14, with significant p < 0.05. From the total, 85% presented ≥1 infection (past or present), 66% with coinfections (≥2 pathogens) (Ehrlichia 75%), and 89% presented clinical alterations. A total of 100% showed anaemia, 70% thrombocytopenia, 61% monocytosis, and 47% neutropenia, among other alterations. Additionally, 11% presented pancytopenia and 59% bicytopenia. The median platelet count was lower in infected dogs (126,000 cells/μL) versus non-infected (221,000 cells/μL) (p = 0.003). Thrombocytopenia was higher among infected dogs (75%) versus non-infected (40%) (p = 0.006), with a 91% positive predictive value for infection. Median neutrophil count was lower in infected dogs (6591 cells/μL) versus non-infected (8804 cells/μL) (p = 0.013). Lymphocytosis occurred only among those infected (27%) (p = 0.022). Leukopenia was only observed among infected dogs (13%). Pancytopenia was only observed among infected dogs. Ehrlichiosis and other hematic infections have led to a significant burden of haematological alterations on infected dogs, including pancytopenia in a tenth of them, most with thrombocytopenia and all anemic.

Original languageEnglish
Article number3460
JournalAnimals
Volume12
Issue number24
DOIs
StatePublished - Dec 2022
Externally publishedYes

Keywords

  • Anaplasma phagocytophilum
  • Anaplasma platys
  • canine
  • complete blood counts
  • Dirofilaria immitis
  • Ehrlichia canis
  • Ehrlichia ewingii
  • hemothropic pathogens
  • Latin America
  • tick-borne diseases
  • zoonotic

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