TY - JOUR
T1 - Genotoxicidad de cloruro de mercurio (II) en alevines de Oreochromis niloticus (Pisces, Cichlidae) expuestos a diferentes temperaturas
AU - Francia-Quiroz, Juan Carlos
AU - Contreras-Luya, Claudia F.
AU - Fernández-Celedonio, Valeria
N1 - Publisher Copyright:
© 2023 Universidad Nacional Mayor de San Marcos. All rights reserved.
PY - 2023
Y1 - 2023
N2 - Mercury chloride (HgCl2) is a neurotoxic, nephrotoxic, and genotoxic compound found in aquatic environments due to anthropogenic activities and whose effect can be altered by variations in temperature (for example: global warming). The aim of this work was to determine the mean lethal concentration (LC50) for HgCl2 and its genotoxic effect, inrelationtotheincreaseintemperaturefor Oreochromis niloticus fingerlings. The LC50 results for HgCl2 during the exposure times (48, 72, and 96 h) and temperatures (28 and 32 °C) showed that the LC50-96h increased from 0.39 mg L-1 for 28 °C to 0.66 mg L-1 for 32 °C. For sublethal evaluation, HgCl2 concentrations from LC50-96h were established for 28 and 32 °C, evaluating genotoxicity for 30 days through the nuclear abnormalities (AN) and micronucleus (MN) assay. A higher frequency of AN and MN was observed at 0.07 mg L-1 of HgCl2 for 32 °C. It is concluded that the LC50 and genotoxicity (AN and MN) for HgCl2 increase with increasing temperature from 28 to 32 °C.
AB - Mercury chloride (HgCl2) is a neurotoxic, nephrotoxic, and genotoxic compound found in aquatic environments due to anthropogenic activities and whose effect can be altered by variations in temperature (for example: global warming). The aim of this work was to determine the mean lethal concentration (LC50) for HgCl2 and its genotoxic effect, inrelationtotheincreaseintemperaturefor Oreochromis niloticus fingerlings. The LC50 results for HgCl2 during the exposure times (48, 72, and 96 h) and temperatures (28 and 32 °C) showed that the LC50-96h increased from 0.39 mg L-1 for 28 °C to 0.66 mg L-1 for 32 °C. For sublethal evaluation, HgCl2 concentrations from LC50-96h were established for 28 and 32 °C, evaluating genotoxicity for 30 days through the nuclear abnormalities (AN) and micronucleus (MN) assay. A higher frequency of AN and MN was observed at 0.07 mg L-1 of HgCl2 for 32 °C. It is concluded that the LC50 and genotoxicity (AN and MN) for HgCl2 increase with increasing temperature from 28 to 32 °C.
KW - chronic assay
KW - mean lethal concentration
KW - micronuclei
KW - nuclear abnormalities
KW - tilapia
UR - http://www.scopus.com/inward/record.url?scp=85159815212&partnerID=8YFLogxK
U2 - 10.15381/rivep.v34i2.23451
DO - 10.15381/rivep.v34i2.23451
M3 - Artículo
AN - SCOPUS:85159815212
SN - 1682-3419
VL - 34
JO - Revista de Investigaciones Veterinarias del Peru
JF - Revista de Investigaciones Veterinarias del Peru
IS - 2
M1 - e23451
ER -