Genital warts in Burmeister's porpoises: Characterization of Phocoena spinipinnis papillomavirus type 1 (PsPV-1) and evidence for a second, distantly related PsPV

Marie Françoise Van Bressem, Patricia Cassonnet, Annabel Rector, Christian Desaintes, Koen Van Waerebeek, Joanna Alfaro-Shigueto, Marc Van Ranst, Gérard Orth

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37 Scopus citations

Abstract

We identified sequences from two distantly related papillomaviruses in genital warts from two Burmeister's porpoises, including a PV antigen-positive specimen, and characterized Phocoena spinipinnis papillomavirus type 1 (PsPV-1). The PsPV-1 genome comprises 7879 nt and presents unusual features. It lacks an E7, an E8 and a bona fide E5 open reading frame (ORF) and has a large E6 ORF. PsPV-1 L1 ORF showed the highest percentage of nucleotide identity (54-55%) with human papillomavirus type 5, bovine papillomavirus type 3 (BPV-3) and Tursiops truncatus papillomavirus type 2 (TtPV-2). This warrants the classification of PsPV-1 as the prototype of the genus Omikronpapillomavirus. PsPV-1 clustered with TtPV-2 in the E6 and E1 E2 phylogenetic trees and with TtPV-2 and BPV-3 in the L2L1 tree. This supports the hypothesis that PV evolution may not be monophyletic across ali genes.

Original languageEnglish
Pages (from-to)1928-1933
Number of pages6
JournalJournal of General Virology
Volume88
Issue number7
DOIs
StatePublished - Jul 2007

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