TY - JOUR
T1 - Genital warts in Burmeister's porpoises
T2 - Characterization of Phocoena spinipinnis papillomavirus type 1 (PsPV-1) and evidence for a second, distantly related PsPV
AU - Van Bressem, Marie Françoise
AU - Cassonnet, Patricia
AU - Rector, Annabel
AU - Desaintes, Christian
AU - Van Waerebeek, Koen
AU - Alfaro-Shigueto, Joanna
AU - Van Ranst, Marc
AU - Orth, Gérard
PY - 2007/7
Y1 - 2007/7
N2 - We identified sequences from two distantly related papillomaviruses in genital warts from two Burmeister's porpoises, including a PV antigen-positive specimen, and characterized Phocoena spinipinnis papillomavirus type 1 (PsPV-1). The PsPV-1 genome comprises 7879 nt and presents unusual features. It lacks an E7, an E8 and a bona fide E5 open reading frame (ORF) and has a large E6 ORF. PsPV-1 L1 ORF showed the highest percentage of nucleotide identity (54-55%) with human papillomavirus type 5, bovine papillomavirus type 3 (BPV-3) and Tursiops truncatus papillomavirus type 2 (TtPV-2). This warrants the classification of PsPV-1 as the prototype of the genus Omikronpapillomavirus. PsPV-1 clustered with TtPV-2 in the E6 and E1 E2 phylogenetic trees and with TtPV-2 and BPV-3 in the L2L1 tree. This supports the hypothesis that PV evolution may not be monophyletic across ali genes.
AB - We identified sequences from two distantly related papillomaviruses in genital warts from two Burmeister's porpoises, including a PV antigen-positive specimen, and characterized Phocoena spinipinnis papillomavirus type 1 (PsPV-1). The PsPV-1 genome comprises 7879 nt and presents unusual features. It lacks an E7, an E8 and a bona fide E5 open reading frame (ORF) and has a large E6 ORF. PsPV-1 L1 ORF showed the highest percentage of nucleotide identity (54-55%) with human papillomavirus type 5, bovine papillomavirus type 3 (BPV-3) and Tursiops truncatus papillomavirus type 2 (TtPV-2). This warrants the classification of PsPV-1 as the prototype of the genus Omikronpapillomavirus. PsPV-1 clustered with TtPV-2 in the E6 and E1 E2 phylogenetic trees and with TtPV-2 and BPV-3 in the L2L1 tree. This supports the hypothesis that PV evolution may not be monophyletic across ali genes.
UR - http://www.scopus.com/inward/record.url?scp=34347345136&partnerID=8YFLogxK
U2 - 10.1099/vir.0.82694-0
DO - 10.1099/vir.0.82694-0
M3 - Artículo
C2 - 17554024
AN - SCOPUS:34347345136
SN - 0022-1317
VL - 88
SP - 1928
EP - 1933
JO - Journal of General Virology
JF - Journal of General Virology
IS - 7
ER -