Factores asociados a mortalidad en pacientes hospitalizados con COVID-19: cohorte prospectiva en un hospital de referencia nacional de Perú

Translated title of the contribution: Factors associated with mortality in patients hospitalized with COVID-19: A prospective cohort in a Peruvian national referral hospital

Miguel A. Vences, Juan J. Pareja-Ramos, Paula Otero, Liz E. Veramendi-Espinoza, Melissa Vega-Villafana, Julissa Mogollón-Lavi, Eduardo Morales-Romero, Josseline Olivera-Vera, Carol Meza, Lucía J. Salas-Lazo, Andy Triveño, Renzo Marín-Dávalos, Ricardo Carpio Rodriguez, Jessica H. Zafra-Tanaka

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Objectives: To describe and assess clinical characteristics and factors associated with mortality in adult patients with COVID-19 admitted to a national referral hospital in Peru. Methods: We conducted a prospective cohort study that included hospitalized patients older than 18 years with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection diagnosis. Patients with a positive rapid serological test on admission but no respiratory symptoms nor compatible images were excluded. We collected the data from clinical records. Results: A total of 813 adults were included, 544 (66.9%) with confirmed COVID-19. The mean age was 61.2 years (standard deviation: 15.0), and 575 (70.5%) were male. The most frequent comorbidities were hypertension (34.1%) and obesity (25.9%). On admission, the most frequent symptoms were dyspnea (82.2%) and cough (53.9%). A total of 114 (14.0%) patients received mechanical ventilation, 38 (4.7%) were admitted to the intensive care unit, and 377 (46.4%) died. The requirement for ventilatory support, greater lung involvement, and inflammatory markers were associated with higher mortality. It was found that for every 10-year age increase, the risk of dying increased 32% (relative risk: 1.32; 95% confidence interval: 1.25 to 1.38). Those who were admitted to the intensive care unit and and were placed on mechanical ventilation had 1.39 (95% confidence interval: 1.13 to 1.69) and 1.97 (95% confidence interval: 1.69 to 2.29) times the risk of dying compared to those who did not, respectively. Conclusion: We found a high mortality rate among hospitalized patients associated with older age, higher inflammatory markers, and greater lung involvement.

Translated title of the contributionFactors associated with mortality in patients hospitalized with COVID-19: A prospective cohort in a Peruvian national referral hospital
Original languageSpanish
Pages (from-to)e8231
JournalMedwave
Volume21
Issue number6
DOIs
StatePublished - 5 Jul 2021
Externally publishedYes

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