Enfermedad de MELAS en Latinoamérica: revisión temática

Translated title of the contribution: MELAS in Latin America

Wilfor Aguirre-Quispe, Mariana Valdez-Taboada, Luis Urbina-Ramírez, Andrea Rivera-Valdivia, Elison Sarapura-Castro, Julio Montoya, Mario Cornejo-Olivas

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

A thematic review on MELAS in Latin America between 1990 and 2021 was conducted through a systematic literature search on LILACs, Scielo, PubMed/Medline and Scopus databases. Nineteen case reports/series out of 966 publications were selected and included 51 patients, 42 of them with genetic diagnosis reported in eight Latin American countries. The m.3243A> G variant was the most frequently reported, the mean age at onset being 12 ± 9.7 years, with a mild female predominance. The most frequent neurological features were stroke-like episodes and seizures. Neuroimaging tests highlighted ischemic stroke-like lesions as well as calcified lesions in the basal ganglia.

Translated title of the contributionMELAS in Latin America
Original languageSpanish
Pages (from-to)316-332
Number of pages17
JournalRevista de Neuro-Psiquiatria
Volume84
Issue number4
DOIs
StatePublished - Oct 2021
Externally publishedYes

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