Distribution of β-lactamases in Acinetobacter baumannii clinical isolates and the effect of Syn 2190 (AmpC inhibitor) on the MICs of different β-lactam antibiotics

Cristina Danes, Margarita M. Navia, Joaquim Ruiz, Francesc Marco, Angels Jurado, M. Teresa Jimenez de Anta, Jordi Vila

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30 Scopus citations

Abstract

The distribution of β-lactamases in a group of 20 epidemiologically well defined Acinetobacter baumannii clinical isolates and the in vitro activity of Syn 2190, a novel β-lactamase AmpC inhibitor, were determined. Twenty-five per cent of the strains carried and expressed a TEM-type β-lactamase, whereas 35% had an OXA-type β-lactamase. In nine out of 11 (82%) ceftazidime-resistant and four out of 13 (30.7%) cefepime-resistant strains, the MIC of these β-lactam antibiotics decreased when determined in the presence of Syn 2190. Thus, our results suggest that in a high percentage of A. baumannii clinical isolates the increased production of AmpC, in combination or not with other resistance mechanisms, contributes to the resistance pattern in A. baumannii to β-lactams.

Original languageEnglish
Pages (from-to)261-264
Number of pages4
JournalJournal of Antimicrobial Chemotherapy
Volume50
Issue number2
DOIs
StatePublished - Aug 2002

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