Abstract
The distribution of β-lactamases in a group of 20 epidemiologically well defined Acinetobacter baumannii clinical isolates and the in vitro activity of Syn 2190, a novel β-lactamase AmpC inhibitor, were determined. Twenty-five per cent of the strains carried and expressed a TEM-type β-lactamase, whereas 35% had an OXA-type β-lactamase. In nine out of 11 (82%) ceftazidime-resistant and four out of 13 (30.7%) cefepime-resistant strains, the MIC of these β-lactam antibiotics decreased when determined in the presence of Syn 2190. Thus, our results suggest that in a high percentage of A. baumannii clinical isolates the increased production of AmpC, in combination or not with other resistance mechanisms, contributes to the resistance pattern in A. baumannii to β-lactams.
Original language | English |
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Pages (from-to) | 261-264 |
Number of pages | 4 |
Journal | Journal of Antimicrobial Chemotherapy |
Volume | 50 |
Issue number | 2 |
DOIs | |
State | Published - Aug 2002 |