Dispersión intercontinental de una cepa de Shigella flexneri resistente a trimetoprima

Translated title of the contribution: Intercontinental spread of a trimethoprim-resistant strain of Shigella flexneri

Margarita M. Navia, Joaquim Ruiz, Jordi Vila

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


INTRODUCTION. In this study we characterize a trimethoprim-resistant strain of Shigella flexneri recovered from stool samples of an international traveler after a trip to Kenya, and analyze its epidemiological relationship with a set of strains having similar characteristics from Tanzania. METHODS. Clonal relationships were studied by three techniques - plasmid profile, repetitive-element (REP)-PCR and pulse-field gel electrophoresis (PFGE). The presence of type 1 integrons was studied by PCR and sequencing. The location and transferability of the detected integron was analyzed by conjugation and PCR. RESULTS. The epidemiological studies showed that all six strains studied belonged to the same clone. Furthermore, all of them carried the same gene encoding for trimethoprim resistance (dfrA7), which was located in an integron within a chromosome. CONCLUSION. Continuous epidemiological surveillance is required to control the spread of pathogenic microorganisms and the dissemination of resistance-encoding genes among geographical areas.

Translated title of the contributionIntercontinental spread of a trimethoprim-resistant strain of Shigella flexneri
Original languageSpanish
Pages (from-to)401-403
Number of pages3
JournalEnfermedades Infecciosas y Microbiologia Clinica
Issue number8
StatePublished - Oct 2003


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