TY - JOUR
T1 - Differences and contributors to global cognitive performance in the underrepresented Latinx Parkinson’s disease population
AU - The Latin American Research consortium on the Genetics of Parkinson’s Disease (LARGE-PD)
AU - Anis, Saar
AU - Chaparro-Solano, Henry Mauricio
AU - Peixoto Leal, Thiago
AU - Sperling, Scott A
AU - Sonneborn, Claire
AU - Callegari Piccinin, Camila
AU - Inca-Martinez, Miguel
AU - Cornejo-Olivas, Mario
AU - Illanes-Manrique, Maryenela
AU - Chana-Cuevas, Pedro
AU - Safie Awad, Paula
AU - Jimena Hernández-Medrano, Ana
AU - Cervantes-Arriaga, Amin
AU - F. S. Schuh, Artur
AU - R. M. Rieder, Carlos
AU - Braga-Neto, Pedro
AU - Andrei da Silva Sena, Antonio
AU - Lopes Santos-Lobato, Bruno
AU - M. Gatto, Emilia
AU - J. Alvarado, Griselda
AU - L. Avila, Cesar
AU - Tumas, Vitor
AU - Foss, Maria Paula
AU - Borges, Vanderci
AU - Ballalai Ferraz, Henrique
AU - Luis Orozco Vélez, Jorge
AU - Muñoz Ospina, Beatriz
AU - Moreno, Sonia
AU - Pineda, David
AU - Esther Rios Pinto, Julia
AU - Olguín, Patricio
AU - Cristobal Nuñez, Juan
AU - Viñuela, Angel
AU - O. Espinal-Martinez, Alan
AU - Mori, Nicanor
AU - Mejía-Rojas, Koni
AU - Medina-Colque, Angel
AU - Lucia Zuma Rosso, Ana
AU - Vilaça, Celmir
AU - Ochoa-Valle, Edward
AU - Cornejo-Herrera, Iván
AU - Reyes-Perez, Paula
AU - Lázaro-Figueroa, Alejandra
AU - Letícia de Moraes Alves, Anna
AU - Gisbert Cury, Rubens
AU - Fernandez, Hubert H.
AU - Mata, Ignacio
N1 - Publisher Copyright:
© 2025 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2025
Y1 - 2025
N2 - Objective: Despite significant progress in understanding the factors influencing cognitive function in Parkinson’s disease (PD), there is a notable gap in data representation for the Latinx population. This study aims to evaluate the contributors to and disparities in cognitive performance among Latinx patients with PD. Methods: A retrospective analysis was conducted based on cross-sectional data encompassing demographic, environmental, motor, and non-motor disease characteristics from the Latin American Research Consortium on the Genetics of PD (LARGE-PD) and the Parkinson’s Progression Markers Initiative (PPMI) cohorts. Linear regression multivariable models were applied to identify variables affecting Montreal Cognitive Assessment (MoCA) scores, accounting for age, sex, and years of education. Results: The analysis comprised of 3,054 PD patients (2,041 from LARGE-PD and 1,013 from PPMI) and 1,303 Latinx-controls. Latinx-PD patients (mean age 63.0 ± 11.8, 56.8% male) exhibited a significantly lower average MoCA score (p <.001) compared to white Non-Hispanic PD patients from PPMI (mean age 67.5 ± 9.9, 61.7% male). This difference persisted when comparing the Latinx-PD to the Latinx-controls (mean age 58.7 ± 9.3, 33.2% male; p <.001). Factors significantly associated with better MoCA scores in Latinx-PD included unilateral symptom onset (p =.009), and higher educational attainment (p <.001). Conversely, those associated with worse scores included the use of dopamine agonists (p =.01), previous tobacco use (p =.01), older age (p <.001), and a higher Hoehn and Yahr scale score (p <.001). Conclusions: Latinx-PD patients demonstrated significantly lower cognitive scores compared to their white non-Hispanic PD counterparts and Latinx-controls. These results highlight the importance of interpreting MoCA scores in a nuanced manner within diverse populations.
AB - Objective: Despite significant progress in understanding the factors influencing cognitive function in Parkinson’s disease (PD), there is a notable gap in data representation for the Latinx population. This study aims to evaluate the contributors to and disparities in cognitive performance among Latinx patients with PD. Methods: A retrospective analysis was conducted based on cross-sectional data encompassing demographic, environmental, motor, and non-motor disease characteristics from the Latin American Research Consortium on the Genetics of PD (LARGE-PD) and the Parkinson’s Progression Markers Initiative (PPMI) cohorts. Linear regression multivariable models were applied to identify variables affecting Montreal Cognitive Assessment (MoCA) scores, accounting for age, sex, and years of education. Results: The analysis comprised of 3,054 PD patients (2,041 from LARGE-PD and 1,013 from PPMI) and 1,303 Latinx-controls. Latinx-PD patients (mean age 63.0 ± 11.8, 56.8% male) exhibited a significantly lower average MoCA score (p <.001) compared to white Non-Hispanic PD patients from PPMI (mean age 67.5 ± 9.9, 61.7% male). This difference persisted when comparing the Latinx-PD to the Latinx-controls (mean age 58.7 ± 9.3, 33.2% male; p <.001). Factors significantly associated with better MoCA scores in Latinx-PD included unilateral symptom onset (p =.009), and higher educational attainment (p <.001). Conversely, those associated with worse scores included the use of dopamine agonists (p =.01), previous tobacco use (p =.01), older age (p <.001), and a higher Hoehn and Yahr scale score (p <.001). Conclusions: Latinx-PD patients demonstrated significantly lower cognitive scores compared to their white non-Hispanic PD counterparts and Latinx-controls. These results highlight the importance of interpreting MoCA scores in a nuanced manner within diverse populations.
KW - Latinx
KW - Montreal cognitive assessment
KW - Parkinson’s disease
KW - cognitive dysfunction
KW - cognitive function
UR - http://www.scopus.com/inward/record.url?scp=85215521631&partnerID=8YFLogxK
U2 - 10.1080/13854046.2025.2450020
DO - 10.1080/13854046.2025.2450020
M3 - Artículo
AN - SCOPUS:85215521631
SN - 1385-4046
JO - Clinical Neuropsychologist
JF - Clinical Neuropsychologist
ER -