Diarrheagenic Escherichia coli in Human Immunodeficiency Virus (HIV) pediatric patients in Lima, Perú

Anicia M. Medina, Fulton P. Rivera, Liliana M. Romero, Lenka A. Kolevic, Maria E. Castillo, Eduardo Verne, Roger Hernandez, Yovanna E. Mayor, Francesca Barletta, Erik Mercado, Theresa J. Ochoa

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

We conducted a prospective study in three hospitals in Lima in human immunodeficiency virus (HIV) children to determine the frequency of diarrheagenic Escherichia coli. Five E. coli colonies/patients were studied by a multiplex real-time polymerase chain reaction to identify the six currently recognized groups of diarrhea-associated E. coli. We have analyzed 70 HIV-associated diarrheal and 70 control samples from HIV-infected children without diarrhea. Among the diarrheal episodes 19% were persistent, 3% dysenteric, and 33% were associated with moderate or severe dehydration. The diarrheagenic E. coli were the most commonly isolated pathogens in diarrhea (19%) and control samples (26%) (P = 0.42), including enteroaggregative (6% versus 10%), enteropathogenic (6% versus 10%), and enterotoxigenic E. coli (4% versus 3%), respectively. The HIV-infected children with diarrhea had the worse age-related immunosuppression, higher viral loads, and were on highly active antiretroviral treatment (HAART) less often than HIV-infected children without diarrhea. Diarrheagenic E. coli were highly resistant to ampicillin (74%) and cotrimoxazole (70%).

Original languageEnglish
Pages (from-to)158-163
Number of pages6
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume83
Issue number1
DOIs
StatePublished - Jul 2010

Fingerprint

Dive into the research topics of 'Diarrheagenic Escherichia coli in Human Immunodeficiency Virus (HIV) pediatric patients in Lima, Perú'. Together they form a unique fingerprint.

Cite this