Diabetes mellitus tipo 1 de inicio tardío y ataxia cerebelosa autoinmune con anti-glutamato descarboxilasa

Sofía Pilar Ildefonso-Najarro; Juan Eduardo Quiroz-Aldave; Guillermo Ramos-Torres; Alejandro Román-González; Jenyfer María Fuentes-Mendoza; Marcio Concepción-Zavaleta; Luis Alberto Concepción-Urteaga

doi:10.15381/anales.v85i4.29193

Diabetes mellitus tipo 1 de inicio tardío y ataxia cerebelosa autoinmune con anti-glutamato descarboxilasa

Translated title of the contribution: Type 1 diabetes mellitus and autoimmune cerebellar ataxia with anti-glutamate decarboxylase

Sofía Pilar Ildefonso-Najarro, Juan Eduardo Quiroz-Aldave, Guillermo Ramos-Torres, Alejandro Román-González, Jenyfer María Fuentes-Mendoza, Marcio Concepción-Zavaleta, Luis Alberto Concepción-Urteaga

Universidad Científica del Sur

Research output: Contribution to journal › Article › peer-review

Abstract

The cerebellar ataxia variant associated with antibodies against glutamic acid decarboxylase 65 (GAD-Ab) is associated with type 1 diabetes mellitus (DM). We present the case of a 63-year-old woman with cerebellar ataxia of unknown origin, who was later diagnosed with T1DM. The identification of GAD-Ab in the cerebrospinal fluid (CSF) demonstrated the association between the two conditions. Diagnosis requires demonstration of increased intrathecal synthesis of GAD-Ab. We emphasize the importance of considering GAD-Ab-associated cerebellar ataxia among the causes of cerebellar ataxia to provide timely and effective treatment.

Translated title of the contribution	Type 1 diabetes mellitus and autoimmune cerebellar ataxia with anti-glutamate decarboxylase
Original language	Spanish
Journal	Anales de la Facultad de Medicina
Volume	85
Issue number	4
DOIs	https://doi.org/10.15381/anales.v85i4.29193
State	Published - 2024

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10.15381/anales.v85i4.29193

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title = "Diabetes mellitus tipo 1 de inicio tard{\'i}o y ataxia cerebelosa autoinmune con anti-glutamato descarboxilasa",

abstract = "The cerebellar ataxia variant associated with antibodies against glutamic acid decarboxylase 65 (GAD-Ab) is associated with type 1 diabetes mellitus (DM). We present the case of a 63-year-old woman with cerebellar ataxia of unknown origin, who was later diagnosed with T1DM. The identification of GAD-Ab in the cerebrospinal fluid (CSF) demonstrated the association between the two conditions. Diagnosis requires demonstration of increased intrathecal synthesis of GAD-Ab. We emphasize the importance of considering GAD-Ab-associated cerebellar ataxia among the causes of cerebellar ataxia to provide timely and effective treatment.",

keywords = "Autoimmunity, Case Reports, Cerebellar Ataxia, Cerebellar Diseases, Paraneoplastic Cerebellar Degeneration, Type 1 Diabetes Mellitus",

author = "Ildefonso-Najarro, {Sof{\'i}a Pilar} and Quiroz-Aldave, {Juan Eduardo} and Guillermo Ramos-Torres and Alejandro Rom{\'a}n-Gonz{\'a}lez and Fuentes-Mendoza, {Jenyfer Mar{\'i}a} and Marcio Concepci{\'o}n-Zavaleta and Concepci{\'o}n-Urteaga, {Luis Alberto}",

year = "2024",

doi = "10.15381/anales.v85i4.29193",

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journal = "Anales de la Facultad de Medicina",

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publisher = "Universidad Nacional Mayor de San Marcos",

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T1 - Diabetes mellitus tipo 1 de inicio tardío y ataxia cerebelosa autoinmune con anti-glutamato descarboxilasa

AU - Ildefonso-Najarro, Sofía Pilar

AU - Quiroz-Aldave, Juan Eduardo

AU - Ramos-Torres, Guillermo

AU - Román-González, Alejandro

AU - Fuentes-Mendoza, Jenyfer María

AU - Concepción-Zavaleta, Marcio

AU - Concepción-Urteaga, Luis Alberto

PY - 2024

Y1 - 2024

N2 - The cerebellar ataxia variant associated with antibodies against glutamic acid decarboxylase 65 (GAD-Ab) is associated with type 1 diabetes mellitus (DM). We present the case of a 63-year-old woman with cerebellar ataxia of unknown origin, who was later diagnosed with T1DM. The identification of GAD-Ab in the cerebrospinal fluid (CSF) demonstrated the association between the two conditions. Diagnosis requires demonstration of increased intrathecal synthesis of GAD-Ab. We emphasize the importance of considering GAD-Ab-associated cerebellar ataxia among the causes of cerebellar ataxia to provide timely and effective treatment.

AB - The cerebellar ataxia variant associated with antibodies against glutamic acid decarboxylase 65 (GAD-Ab) is associated with type 1 diabetes mellitus (DM). We present the case of a 63-year-old woman with cerebellar ataxia of unknown origin, who was later diagnosed with T1DM. The identification of GAD-Ab in the cerebrospinal fluid (CSF) demonstrated the association between the two conditions. Diagnosis requires demonstration of increased intrathecal synthesis of GAD-Ab. We emphasize the importance of considering GAD-Ab-associated cerebellar ataxia among the causes of cerebellar ataxia to provide timely and effective treatment.

KW - Autoimmunity

KW - Case Reports

KW - Cerebellar Ataxia

KW - Cerebellar Diseases

KW - Paraneoplastic Cerebellar Degeneration

KW - Type 1 Diabetes Mellitus

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U2 - 10.15381/anales.v85i4.29193

DO - 10.15381/anales.v85i4.29193

M3 - Artículo

AN - SCOPUS:85211732300

SN - 1025-5583

VL - 85

JO - Anales de la Facultad de Medicina

JF - Anales de la Facultad de Medicina

IS - 4

ER -

Diabetes mellitus tipo 1 de inicio tardío y ataxia cerebelosa autoinmune con anti-glutamato descarboxilasa

Abstract

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