TY - JOUR
T1 - Congenital microcephaly
T2 - A diagnostic challenge during Zika epidemics
AU - Alvarado-Socarras, Jorge L.
AU - Idrovo, Álvaro J.
AU - Contreras-García, Gustavo A.
AU - Rodriguez-Morales, Alfonso J.
AU - Audcent, Tobey A.
AU - Mogollon-Mendoza, Adriana C.
AU - Paniz-Mondolfi, Alberto
N1 - Publisher Copyright:
© 2018 Elsevier Ltd
PY - 2018/5/1
Y1 - 2018/5/1
N2 - The multiple, wide and diverse etiologies of congenital microcephaly are complex and multifactorial. Recent advances in genetic testing have improved understanding of novel genetic causes of congenital microcephaly. The recent Zika virus (ZIKV) epidemic in Latin America has highlighted the need for a better understanding of the underlying pathological mechanisms of microcephaly including both infectious and non-infectious causes. The diagnostic approach to microcephaly needs to include potential infectious and genetic etiologies, as well as environmental in-utero exposures such as alcohol, toxins, and medications. Emerging genetic alterations linked to microcephaly include abnormal mitotic microtubule spindle structure and abnormal function of centrosomes. We discuss the diagnostic challenge of congenital microcephaly in the context of understanding the links with ZIKV emergence as a new etiological factor involved in this birth defect.
AB - The multiple, wide and diverse etiologies of congenital microcephaly are complex and multifactorial. Recent advances in genetic testing have improved understanding of novel genetic causes of congenital microcephaly. The recent Zika virus (ZIKV) epidemic in Latin America has highlighted the need for a better understanding of the underlying pathological mechanisms of microcephaly including both infectious and non-infectious causes. The diagnostic approach to microcephaly needs to include potential infectious and genetic etiologies, as well as environmental in-utero exposures such as alcohol, toxins, and medications. Emerging genetic alterations linked to microcephaly include abnormal mitotic microtubule spindle structure and abnormal function of centrosomes. We discuss the diagnostic challenge of congenital microcephaly in the context of understanding the links with ZIKV emergence as a new etiological factor involved in this birth defect.
KW - Latin America
KW - Microcephaly
KW - Pregnancy infections
KW - TORCH
KW - Zika
UR - http://www.scopus.com/inward/record.url?scp=85042645387&partnerID=8YFLogxK
U2 - 10.1016/j.tmaid.2018.02.002
DO - 10.1016/j.tmaid.2018.02.002
M3 - Artículo de revisión
C2 - 29471046
AN - SCOPUS:85042645387
SN - 1477-8939
VL - 23
SP - 14
EP - 20
JO - Travel Medicine and Infectious Disease
JF - Travel Medicine and Infectious Disease
ER -
