Resistencia a la colistina en cepas de klebsiella pneumoniae multidrogorresistente del período 2015-2018 en un instituto materno perinatal de Lima, Peru

Translated title of the contribution: Colistin resistance in multidrug-resistant klebsiella pneumoniae strains at a perinatal maternal institute in Lima, Peru, 2015-2018

Andrea Naomi-Matsuoka, Marina Vargas, Barbara Ymaña, Gabriela Soza, Maria J. Pons

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The objective of this study was to evaluate the presence of colistin-and carbapenemic-resistant genes in multidrug-resistant Klebsiella pneumoniae strains isolated at the Instituto Materno Perinatal de Lima (2015-2018). Susceptibility levels were analyzed by disk diffusion and microdilution. The presence of colistin-and carbapenemic-resistant genes was determined by polymerase chain reaction (PCR) and was related to clonality. A total of 36 K. pneumoniae strains were analyzed, 5 (13.8%) were resistant to colistin and belonged to different clonal groups. Only 2 strains were found with carbapenemases (blaKPC and blaNDM), and no colistin plasmid genes were detected. High resistance levels to the other tested antimicrobials were observed, except for amikacin (13.9%). The results highlight the presence of colistinresistant strains (33.3% in 2018), a worrying situation as they are part of the latest treatment alternatives for infections caused by multiresistant pathogens.

Translated title of the contributionColistin resistance in multidrug-resistant klebsiella pneumoniae strains at a perinatal maternal institute in Lima, Peru, 2015-2018
Original languageSpanish
Pages (from-to)716-720
Number of pages5
JournalRevista Peruana de Medicina Experimental y Salud Publica
Volume37
Issue number4
DOIs
StatePublished - 1 Oct 2020

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