TY - JOUR
T1 - Cloning and nucleotide sequence analysis of a gene encoding an OXA- derived β-lactamase in Acinetobacter baumannii
AU - Vila, Jordi
AU - Navia, Margarita
AU - Ruiz, Joaquim
AU - Casals, Climent
PY - 1997/12
Y1 - 1997/12
N2 - A clinical strain of Acinetobacter baumannii (strain Ab41) that was resistant to all β-lactam antibiotics tested except ceftazidime, ceftriaxone, ceftizoxime, and imipenam produced three β-lactamases: a presumptive chromosomal cephalosporinase, a TEM-1-like β-lactamase (pI 5.4), and a novel OXA-derived β-lactamase named OXA-21 (pI 7.0). The gene encoding OXA-21 was located in an integron. The nucleotide sequence showed three mutations compared with the sequence of OXA-3, with two being silent; the nonsilent mutation generated a substitution of Ile-217 to Met.
AB - A clinical strain of Acinetobacter baumannii (strain Ab41) that was resistant to all β-lactam antibiotics tested except ceftazidime, ceftriaxone, ceftizoxime, and imipenam produced three β-lactamases: a presumptive chromosomal cephalosporinase, a TEM-1-like β-lactamase (pI 5.4), and a novel OXA-derived β-lactamase named OXA-21 (pI 7.0). The gene encoding OXA-21 was located in an integron. The nucleotide sequence showed three mutations compared with the sequence of OXA-3, with two being silent; the nonsilent mutation generated a substitution of Ile-217 to Met.
UR - http://www.scopus.com/inward/record.url?scp=0030777048&partnerID=8YFLogxK
U2 - 10.1128/aac.41.12.2757
DO - 10.1128/aac.41.12.2757
M3 - Comentario/Debate
C2 - 9420053
AN - SCOPUS:0030777048
SN - 0066-4804
VL - 41
SP - 2757
EP - 2759
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 12
ER -
