TY - JOUR
T1 - Clinical Manifestations
AU - Montesinos, Rosa
AU - Custodio, Belen
AU - Malaga, Marco
AU - Chambergo-Michilot, Diego
AU - Verastegui, Graciet
AU - Agüero-Flores, Katherine
AU - Alejos-Zirena, Juan
AU - Andamayo-Villalba, Luis
AU - Seminario G, Wendy
AU - Custodio, Nilton
N1 - Publisher Copyright:
© 2024 The Alzheimer's Association. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
PY - 2024/12/1
Y1 - 2024/12/1
N2 - BACKGROUND: People caring of individuals with dementia are prone to suffering from burden. Behavioral and psychological symptoms of dementia (BPSD) may have an impact on caregiver burden. In Latin American countries there is lack of research on caregiver burden. We aimed to determine which BPSD have the greatest impact on caregiver burden among Peruvian patients with dementia; and to compare the effects of BPSD on caregiver burden across different types of dementia. METHODS: Cross-sectional study of 231 patients living with Alzheimer's dementia (AD), behavioral variant frontotemporal dementia (bvFTD), dementia with Lewy bodies (DLB) and vascular dementia (VD), and their caregivers attended in a Peruvian memory clinic. BPSD were assessed with the Neuropsychiatric Inventory (NPI). Caregiver burden was assessed with the Zarit Burden Inventory (ZBI). We used analysis of variance to compare the groups of AD, bvFTD, DLB and VD. Correlations between ZBI and NPI subscale scores were assessed with Spearman's correlation. RESULTS: DLB caregivers had significantly higher levels of burden than the other patient groups (P < 0.05), and higher total NPI scores than caregivers for other patient groups (P < 0.05). bvFTD caregivers had significantly higher total NPI scores than AD and VD caregivers (P < 0.05). Hallucinations, aberrant motor behavior, and apathy were the symptoms most significantly correlated with caregiver burden in those caring for DLB, bvFTD, and AD patients, respectively. CONCLUSIONS: Neuropsychiatric symptoms are higher in DLB caregivers. Hallucinations, aberrant motor behavior, and apathy are the main symptoms correlated with burden.
AB - BACKGROUND: People caring of individuals with dementia are prone to suffering from burden. Behavioral and psychological symptoms of dementia (BPSD) may have an impact on caregiver burden. In Latin American countries there is lack of research on caregiver burden. We aimed to determine which BPSD have the greatest impact on caregiver burden among Peruvian patients with dementia; and to compare the effects of BPSD on caregiver burden across different types of dementia. METHODS: Cross-sectional study of 231 patients living with Alzheimer's dementia (AD), behavioral variant frontotemporal dementia (bvFTD), dementia with Lewy bodies (DLB) and vascular dementia (VD), and their caregivers attended in a Peruvian memory clinic. BPSD were assessed with the Neuropsychiatric Inventory (NPI). Caregiver burden was assessed with the Zarit Burden Inventory (ZBI). We used analysis of variance to compare the groups of AD, bvFTD, DLB and VD. Correlations between ZBI and NPI subscale scores were assessed with Spearman's correlation. RESULTS: DLB caregivers had significantly higher levels of burden than the other patient groups (P < 0.05), and higher total NPI scores than caregivers for other patient groups (P < 0.05). bvFTD caregivers had significantly higher total NPI scores than AD and VD caregivers (P < 0.05). Hallucinations, aberrant motor behavior, and apathy were the symptoms most significantly correlated with caregiver burden in those caring for DLB, bvFTD, and AD patients, respectively. CONCLUSIONS: Neuropsychiatric symptoms are higher in DLB caregivers. Hallucinations, aberrant motor behavior, and apathy are the main symptoms correlated with burden.
UR - http://www.scopus.com/inward/record.url?scp=85214589283&partnerID=8YFLogxK
U2 - 10.1002/alz.090795
DO - 10.1002/alz.090795
M3 - Artículo
C2 - 39750493
AN - SCOPUS:85214589283
SN - 1552-5260
VL - 20
SP - e090795
JO - Alzheimer's and Dementia
JF - Alzheimer's and Dementia
ER -