Caracterización de escherichia coli d7111 productora de β-lactamasa tem-176

Translated title of the contribution: Characterization of escherichia coli d7111 producing the β-lactamase tem-176

Joaquim Ruiz, Maria J. Pons, Susan Mosquito, Theresa J. Ochoa, Yolanda Sáenz

Research output: Contribution to journalArticlepeer-review

Abstract

The present report is the original description of blaTEM-176. The mechanisms of resistance to antimicrobial agents were determined in an enterotoxigenic Escherichia coli, determining the susceptibility to 22 antimicrobials classified in 15 different groups by agar diffusion and establishing the phylogenetic group, mechanisms of resistance and presence of Class 1 and 2 integrons. Integrons and β-lactam resistance genes were sequenced. The isolate, belonging to phylogenetic group A, showed the presence of resistance or diminished susceptibility to a ampicillin, amoxicillin plus clavulanic acid, nalidíxic acid, ciprofloxacin, streptomycin, kanamycin, tetracycline, trimethoprim, sulfisoxazole, cotrimoxazole, azithromycin and nitrofurantoin, carrying blaTEM, aadA1/2, aphA1, sul3, tet(A) and a Class 2 integron containing a dfrA1 gene. Quinolone resistance was related to the substitution Ser83 Ala. The TEM sequencing showed the presence of the new substitution Ala222 Val, which led to the description of the new β-lactamase blaTEM-176 .

Translated title of the contributionCharacterization of escherichia coli d7111 producing the β-lactamase tem-176
Original languageSpanish
Pages (from-to)130-135
Number of pages6
JournalRevista Peruana de Medicina Experimental y Salud Publica
Volume38
Issue number1
DOIs
StatePublished - 2021

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