Characterization of an integron carrying a new class D β-lactamase (OXA-37) in Acinetobacter baumannii

Margarita M. Navia; Joaquim Ruiz; Jordi Vila

doi:10.1089/10766290260469516

Characterization of an integron carrying a new class D β-lactamase (OXA-37) in Acinetobacter baumannii

Margarita M. Navia, Joaquim Ruiz, Jordi Vila

Medicina humana

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

Integrons from a clinical strain of Acinetobacter baumannii highly resistant to β-lactams have been analyzed. The largest (2.2 kb) contained three gene cassettes: an aacA4, an open reading frame of 417 nucleotides, and an OXA-type encoding gene. The oxa gene nucleotide sequence differed from that of the oxa-20 in 2 bp, one of the mutations being silent. The nonsilent mutation generated a substitution of glutamic acid for aspartic acid. The new OXA has been named OXA-37.

Original language	English
Pages (from-to)	261-265
Number of pages	5
Journal	Microbial Drug Resistance
Volume	8
Issue number	4
DOIs	https://doi.org/10.1089/10766290260469516
State	Published - 2002

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abstract = "Integrons from a clinical strain of Acinetobacter baumannii highly resistant to β-lactams have been analyzed. The largest (2.2 kb) contained three gene cassettes: an aacA4, an open reading frame of 417 nucleotides, and an OXA-type encoding gene. The oxa gene nucleotide sequence differed from that of the oxa-20 in 2 bp, one of the mutations being silent. The nonsilent mutation generated a substitution of glutamic acid for aspartic acid. The new OXA has been named OXA-37.",

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AB - Integrons from a clinical strain of Acinetobacter baumannii highly resistant to β-lactams have been analyzed. The largest (2.2 kb) contained three gene cassettes: an aacA4, an open reading frame of 417 nucleotides, and an OXA-type encoding gene. The oxa gene nucleotide sequence differed from that of the oxa-20 in 2 bp, one of the mutations being silent. The nonsilent mutation generated a substitution of glutamic acid for aspartic acid. The new OXA has been named OXA-37.

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U2 - 10.1089/10766290260469516

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ER -

Characterization of an integron carrying a new class D β-lactamase (OXA-37) in Acinetobacter baumannii

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