Cardiac myxoma in the pulmonary trunk of a canine: Presence of mesenchymal stem-like cells

Luis Alfaro, Alexis Enciso, Javier Enciso

Research output: Contribution to journalArticlepeer-review

Abstract

Cardiac myxoma is a rare disease in dogs. Its histogenic origin has not yet been established, but the involvement of mesenchymal stem cells has been suggested in humans. Here we report an encapsulated and benign cardiac myxoma located at the entrance to the pulmonary trunk of the heart of an 8-year-old male Yorkshire Terrier dog presenting sudden death in the absence of clinical symptoms related to cardiac alterations. Hematoxylin/eosin staining demonstrated the mixoid origin of the myxoma, showing abundant hypocellular stroma with polygonal cells, while immunohistochemistry (IHC) corroborated its mesenchymal lineage with the detection of vimentin and α-SMA positive cell populations. In addition, IHC showed some cell populations in the stroma to be immunoreactive to the pluripotency markers Oct4 and ALDH1. In conclusion, this is the first report of the presence of mesenchymal stem-like cells with an Oct4 and ALDH1-positive IHC profile in a canine cardiac myxoma.

Original languageEnglish
Pages (from-to)431-434
Number of pages4
JournalThai Journal of Veterinary Medicine
Volume50
Issue number3
StatePublished - Sep 2020

Keywords

  • Canine cardiac myxoma
  • Mesenchymal stem-like cells
  • Mesenchymal tumor

Fingerprint

Dive into the research topics of 'Cardiac myxoma in the pulmonary trunk of a canine: Presence of mesenchymal stem-like cells'. Together they form a unique fingerprint.

Cite this