TY - JOUR
T1 - Cancer and depression in older adults
AU - Villanueva-Salazar, Raúl
AU - Díaz-Baquerizo, Adriana
AU - Tintaya-Pelaes, Ana L.
AU - Estela-Fernández, Cielo A.
AU - Parodi, José F.
AU - Runzer-Colmenares, Fernando
N1 - Publisher Copyright:
© 2024 Sociedad Mexicana de Oncología. Published by Permanyer.
PY - 2024/10
Y1 - 2024/10
N2 - Background: Oncological diseases lead to the expression of multiple adverse reactions, which can be physical or mental. Objective: To determine the association between adverse reactions in older people undergoing oncological treatment and depression. Method: Observational design, retrospective cohort type. The population consisted of men aged 60 years or older with cancer. Depression was analysed as a risk factor in the presentation of adverse reactions to oncological treatment. Results: A total of 24.62% (n = 277) presented adverse reactions to treatment. A mean of 2.89 was found in the Yesavage score, finding an increase in the questionnaire in relation to the number of adverse reactions. This correlation was quantified in a linear regression model adjusted for sociodemographic and geriatric assessment variables, finding a β coefficient of 1.99 with a 95% confidence interval of 1.13-3.22 (p < 0.01), and in a model adjusted for oncological assessment variables, calculating a β coefficient of 1.32 with a 95% confidence interval of 1.13-1.79 (p < 0.01). Conclusions: Adverse reactions were associated with an even higher score on the Yesavage questionnaire, which would suggest a relationship between depression and greater adverse reactions.
AB - Background: Oncological diseases lead to the expression of multiple adverse reactions, which can be physical or mental. Objective: To determine the association between adverse reactions in older people undergoing oncological treatment and depression. Method: Observational design, retrospective cohort type. The population consisted of men aged 60 years or older with cancer. Depression was analysed as a risk factor in the presentation of adverse reactions to oncological treatment. Results: A total of 24.62% (n = 277) presented adverse reactions to treatment. A mean of 2.89 was found in the Yesavage score, finding an increase in the questionnaire in relation to the number of adverse reactions. This correlation was quantified in a linear regression model adjusted for sociodemographic and geriatric assessment variables, finding a β coefficient of 1.99 with a 95% confidence interval of 1.13-3.22 (p < 0.01), and in a model adjusted for oncological assessment variables, calculating a β coefficient of 1.32 with a 95% confidence interval of 1.13-1.79 (p < 0.01). Conclusions: Adverse reactions were associated with an even higher score on the Yesavage questionnaire, which would suggest a relationship between depression and greater adverse reactions.
KW - adverse reactions
KW - Cancer
KW - Depression
KW - Drug-related side effects
KW - Geriatrics
UR - http://www.scopus.com/inward/record.url?scp=85213850903&partnerID=8YFLogxK
U2 - 10.24875/j.gamo.M24000270
DO - 10.24875/j.gamo.M24000270
M3 - Artículo
AN - SCOPUS:85213850903
SN - 1665-9201
VL - 23
JO - Gaceta Mexicana de Oncologia
JF - Gaceta Mexicana de Oncologia
IS - 4
ER -