Cancer and depression in older adults

Raúl Villanueva-Salazar, Adriana Díaz-Baquerizo, Ana L. Tintaya-Pelaes, Cielo A. Estela-Fernández, José F. Parodi, Fernando Runzer-Colmenares

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Oncological diseases lead to the expression of multiple adverse reactions, which can be physical or mental. Objective: To determine the association between adverse reactions in older people undergoing oncological treatment and depression. Method: Observational design, retrospective cohort type. The population consisted of men aged 60 years or older with cancer. Depression was analysed as a risk factor in the presentation of adverse reactions to oncological treatment. Results: A total of 24.62% (n = 277) presented adverse reactions to treatment. A mean of 2.89 was found in the Yesavage score, finding an increase in the questionnaire in relation to the number of adverse reactions. This correlation was quantified in a linear regression model adjusted for sociodemographic and geriatric assessment variables, finding a β coefficient of 1.99 with a 95% confidence interval of 1.13-3.22 (p < 0.01), and in a model adjusted for oncological assessment variables, calculating a β coefficient of 1.32 with a 95% confidence interval of 1.13-1.79 (p < 0.01). Conclusions: Adverse reactions were associated with an even higher score on the Yesavage questionnaire, which would suggest a relationship between depression and greater adverse reactions.

Translated title of the contributionCáncer y depresión en adultos mayores
Original languageEnglish
JournalGaceta Mexicana de Oncologia
Volume23
Issue number4
DOIs
StatePublished - Oct 2024

Keywords

  • adverse reactions
  • Cancer
  • Depression
  • Drug-related side effects
  • Geriatrics

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