TY - JOUR
T1 - Breast-conserving surgery vs. total mastectomy in patients with triple negative breast cancer in early stages
T2 - A propensity score analysis
AU - De-La-Cruz-Ku, Gabriel
AU - Valcarcel, Bryan
AU - Morante, Zaida
AU - Möller, Mecker G.
AU - Lizandro, Sofia
AU - Rebaza, Lia P.
AU - Enriquez, Daniel
AU - Luque, Renato
AU - Luján-Peche, María G.
AU - Eyzaguirre-Sandoval, Miguel E.
AU - Saavedra, Antonella
AU - Razuri, Cesar
AU - Pinto, Joseph A.
AU - Fuentes, Hugo A.
AU - Neciosup, Silvia P.
AU - Gomez, Henry L.
N1 - Publisher Copyright:
© 2020 IOS Press and the authors. All rights reserved.
PY - 2020
Y1 - 2020
N2 - BACKGROUND: Breast-conserving surgery (BCS) as an alternative to total mastectomy (TM) in patients with early-stage triple-negative breast cancer (TNBC) is not widely spread. OBJECTIVE: We aimed to compare the overall survival (OS) and disease-free survival (DFS) between both surgical approaches in early-stage TNBC patients at 10 years. METHODS: We conducted a retrospective cohort study in TNBC female patients with stage I-IIa, treated at a single-center during the period of 2000-2014. We estimated and compared the survival rates with the Kaplan Meier and Long-rank test. Propensity scores were calculated with the generalized boosted regression model and were used in the multivariate Cox regression analysis with the covariate adjustment method. RESULTS: We included 288 patients, 111 in the BCS vs. 177 in the TM group. The median follow-up was 102 months. Moreover, the patients in the BCS group had superior OS (85% vs. 81%, p = 0.56) and DFS (83% vs. 80%, p = 0.42) at 10 years. In the multivariate Cox analysis, BCS decreased the mortality risk (HR: 0.79, 95% CI: 0.37-1.67, p = 0.538), and the locoregional or distant recurrence risk (HR: 0.67, 95% CI: 0.32-1.41, p = 0.294), albeit with no statistical significance. CONCLUSION: BCS is a safe alternative to TM in Latin-American patients with early-stage TNBC.
AB - BACKGROUND: Breast-conserving surgery (BCS) as an alternative to total mastectomy (TM) in patients with early-stage triple-negative breast cancer (TNBC) is not widely spread. OBJECTIVE: We aimed to compare the overall survival (OS) and disease-free survival (DFS) between both surgical approaches in early-stage TNBC patients at 10 years. METHODS: We conducted a retrospective cohort study in TNBC female patients with stage I-IIa, treated at a single-center during the period of 2000-2014. We estimated and compared the survival rates with the Kaplan Meier and Long-rank test. Propensity scores were calculated with the generalized boosted regression model and were used in the multivariate Cox regression analysis with the covariate adjustment method. RESULTS: We included 288 patients, 111 in the BCS vs. 177 in the TM group. The median follow-up was 102 months. Moreover, the patients in the BCS group had superior OS (85% vs. 81%, p = 0.56) and DFS (83% vs. 80%, p = 0.42) at 10 years. In the multivariate Cox analysis, BCS decreased the mortality risk (HR: 0.79, 95% CI: 0.37-1.67, p = 0.538), and the locoregional or distant recurrence risk (HR: 0.67, 95% CI: 0.32-1.41, p = 0.294), albeit with no statistical significance. CONCLUSION: BCS is a safe alternative to TM in Latin-American patients with early-stage TNBC.
KW - Triple negative breast cancer neoplasm
KW - adjuvant chemotherapy
KW - breast-conserving surgery; overall survival
KW - distant disease-free survival
UR - http://www.scopus.com/inward/record.url?scp=85079780845&partnerID=8YFLogxK
U2 - 10.3233/BD-190391
DO - 10.3233/BD-190391
M3 - Artículo
C2 - 31903977
AN - SCOPUS:85079780845
SN - 0888-6008
VL - 39
SP - 29
EP - 35
JO - Breast Disease
JF - Breast Disease
IS - 1
ER -
