Antimicrobial resistance of Vibrio cholerae O1 serotype Ogawa isolated in Manhiça District Hospital, southern Mozambique

Inácio Mandomando; Mateu Espasa; Xavier Vallès; Jahit Sacarlal; Betuel Sigaúque; Joaquim Ruiz; Pedro Alonso

doi:10.1093/jac/dkm257

Antimicrobial resistance of Vibrio cholerae O1 serotype Ogawa isolated in Manhiça District Hospital, southern Mozambique

Inácio Mandomando, Mateu Espasa, Xavier Vallès, Jahit Sacarlal, Betuel Sigaúque, Joaquim Ruiz, Pedro Alonso

Medicina humana

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

Objectives: To describe the antimicrobial susceptibility profile of isolated Vibrio cholerae O1 serotype Ogawa recovered from patients admitted to the cholera facility in the Manhiça District Hospital (MDH), Mozambique. Methods: Rectal swabs were collected from patients with complaints symptomatic of cholera admitted to the MDH cholera facility. Samples were processed for V. cholerae isolation at the Centro de Investigação em Saúde da Manhiça (CISM) and identified by biochemical reaction. Serotypes were determined by slide-agglutination antisera. Susceptibilities were determined by disc diffusion. Results: Seventy-seven isolates were examined for their resistance profile. High incidences of antimicrobial resistance were found for chloramphenicol (57.9%), co-trimoxazole (96.6%) and tetracycline (97.3%). Quinolone resistance remained low (4.2%). Conclusions: Although V. cholerae infections in Africa do not usually require antimicrobial treatment, strains in rural Mozambique show high incidences of resistance to readily available drugs. When appropriate, quinolones or third-generation cephalosporins can be used as treatment options.

Original language	English
Pages (from-to)	662-664
Number of pages	3
Journal	Journal of Antimicrobial Chemotherapy
Volume	60
Issue number	3
DOIs	https://doi.org/10.1093/jac/dkm257
State	Published - Sep 2007

Keywords

Cholera
Diarrhoea
Susceptibility profile

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/jac/dkm257

Cite this

@article{0e50822df22c4557bf3ea3641c3145d0,

title = "Antimicrobial resistance of Vibrio cholerae O1 serotype Ogawa isolated in Manhi{\c c}a District Hospital, southern Mozambique",

abstract = "Objectives: To describe the antimicrobial susceptibility profile of isolated Vibrio cholerae O1 serotype Ogawa recovered from patients admitted to the cholera facility in the Manhi{\c c}a District Hospital (MDH), Mozambique. Methods: Rectal swabs were collected from patients with complaints symptomatic of cholera admitted to the MDH cholera facility. Samples were processed for V. cholerae isolation at the Centro de Investiga{\c c}{\~a}o em Sa{\'u}de da Manhi{\c c}a (CISM) and identified by biochemical reaction. Serotypes were determined by slide-agglutination antisera. Susceptibilities were determined by disc diffusion. Results: Seventy-seven isolates were examined for their resistance profile. High incidences of antimicrobial resistance were found for chloramphenicol (57.9%), co-trimoxazole (96.6%) and tetracycline (97.3%). Quinolone resistance remained low (4.2%). Conclusions: Although V. cholerae infections in Africa do not usually require antimicrobial treatment, strains in rural Mozambique show high incidences of resistance to readily available drugs. When appropriate, quinolones or third-generation cephalosporins can be used as treatment options.",

keywords = "Cholera, Diarrhoea, Susceptibility profile",

author = "In{\'a}cio Mandomando and Mateu Espasa and Xavier Vall{\`e}s and Jahit Sacarlal and Betuel Siga{\'u}que and Joaquim Ruiz and Pedro Alonso",

note = "Funding Information: We thank the Manhic¸a Health District Authorities, and special thanks to Mariano Sita{\'u}be of the bacteriology laboratory at the CISM for supporting us in culturing and identifying Vibrio strains. CSI is also supported by RICET and RCESP networks. Joaquim Ruiz is the recipient of grants CP05/00130 and PI06/ 0204 from the Fondo de Investigaciones Sanitarias, Spain. Funding Information: This project was supported by Fundaci{\'o} Clinic and Agencia Espanhola de Cooperacion Internacional (AECI).",

year = "2007",

month = sep,

doi = "10.1093/jac/dkm257",

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volume = "60",

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journal = "Journal of Antimicrobial Chemotherapy",

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T1 - Antimicrobial resistance of Vibrio cholerae O1 serotype Ogawa isolated in Manhiça District Hospital, southern Mozambique

AU - Mandomando, Inácio

AU - Espasa, Mateu

AU - Vallès, Xavier

AU - Sacarlal, Jahit

AU - Sigaúque, Betuel

AU - Ruiz, Joaquim

AU - Alonso, Pedro

N1 - Funding Information: We thank the Manhic¸a Health District Authorities, and special thanks to Mariano Sitaúbe of the bacteriology laboratory at the CISM for supporting us in culturing and identifying Vibrio strains. CSI is also supported by RICET and RCESP networks. Joaquim Ruiz is the recipient of grants CP05/00130 and PI06/ 0204 from the Fondo de Investigaciones Sanitarias, Spain. Funding Information: This project was supported by Fundació Clinic and Agencia Espanhola de Cooperacion Internacional (AECI).

PY - 2007/9

Y1 - 2007/9

N2 - Objectives: To describe the antimicrobial susceptibility profile of isolated Vibrio cholerae O1 serotype Ogawa recovered from patients admitted to the cholera facility in the Manhiça District Hospital (MDH), Mozambique. Methods: Rectal swabs were collected from patients with complaints symptomatic of cholera admitted to the MDH cholera facility. Samples were processed for V. cholerae isolation at the Centro de Investigação em Saúde da Manhiça (CISM) and identified by biochemical reaction. Serotypes were determined by slide-agglutination antisera. Susceptibilities were determined by disc diffusion. Results: Seventy-seven isolates were examined for their resistance profile. High incidences of antimicrobial resistance were found for chloramphenicol (57.9%), co-trimoxazole (96.6%) and tetracycline (97.3%). Quinolone resistance remained low (4.2%). Conclusions: Although V. cholerae infections in Africa do not usually require antimicrobial treatment, strains in rural Mozambique show high incidences of resistance to readily available drugs. When appropriate, quinolones or third-generation cephalosporins can be used as treatment options.

AB - Objectives: To describe the antimicrobial susceptibility profile of isolated Vibrio cholerae O1 serotype Ogawa recovered from patients admitted to the cholera facility in the Manhiça District Hospital (MDH), Mozambique. Methods: Rectal swabs were collected from patients with complaints symptomatic of cholera admitted to the MDH cholera facility. Samples were processed for V. cholerae isolation at the Centro de Investigação em Saúde da Manhiça (CISM) and identified by biochemical reaction. Serotypes were determined by slide-agglutination antisera. Susceptibilities were determined by disc diffusion. Results: Seventy-seven isolates were examined for their resistance profile. High incidences of antimicrobial resistance were found for chloramphenicol (57.9%), co-trimoxazole (96.6%) and tetracycline (97.3%). Quinolone resistance remained low (4.2%). Conclusions: Although V. cholerae infections in Africa do not usually require antimicrobial treatment, strains in rural Mozambique show high incidences of resistance to readily available drugs. When appropriate, quinolones or third-generation cephalosporins can be used as treatment options.

KW - Cholera

KW - Diarrhoea

KW - Susceptibility profile

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DO - 10.1093/jac/dkm257

M3 - Artículo

C2 - 17626024

AN - SCOPUS:34548138989

SN - 0305-7453

VL - 60

SP - 662

EP - 664

JO - Journal of Antimicrobial Chemotherapy

JF - Journal of Antimicrobial Chemotherapy

IS - 3

ER -

Antimicrobial resistance of Vibrio cholerae O1 serotype Ogawa isolated in Manhiça District Hospital, southern Mozambique

Abstract

Keywords

UN SDGs

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