Antimicrobial drug resistance trends of bacteremia isolates in a rural hospital in southern Mozambique

Inácio Mandomando, Betuel Sigaúque, Luis Morais, Mateu Espasa, Xavier Vallès, Jahit Sacarlal, Eusébio Macete, Pedro Aide, Llorenç Quintò, Tacilta Nhampossa, Sónia Machevo, Quique Bassat, Clara Menéndez, Joaquim Ruiz, Anna Roca, Pedro L. Alonso

Research output: Contribution to journalArticlepeer-review

53 Scopus citations


Antibiotic resistance in Africa is increasing but insufficiently recognized as a public health problem. However, there are scarce data for antimicrobial resistance trends among bloodstream isolates in sub-Saharan Africa. Antimicrobial drug resistance trends among bacteria isolated from blood of children < 15 years of age admitted to the Manhiça District Hospital in Mozambique during May 2001-April 2006 were monitored by disk diffusion. We documented a linear trend of increasing resistance throughout the study period to chloramphenicol among isolates of Non-typhi Salmonella (P < 0.001), Escherichia coli (P = 0.002), Staphylococcus aureus (P < 0.001), and Haemophilus influenzae (P < 0.001). Increasing resistance to ampicillin was also observed for H. influenzae isolates (P < 0.001). We report trends of increasing resistance among the most frequent etiologies of bacteremia to the most commonly used antibiotics for empirical therapy in this community. Quinolones and third-generation cephalosporines may be needed in the short term to manage community-acquired infections.

Original languageEnglish
Pages (from-to)152-157
Number of pages6
JournalAmerican Journal of Tropical Medicine and Hygiene
Issue number1
StatePublished - Jul 2010


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