Antibacterial Efficacy against Streptococcus mutans of Different Desensitizing Dentifrices: A Comparison In vitro Study

Mariela Romo, Roman Mendoza, Franco Mauricio, Lucy Chiong, Arnaldo Munive-Degregori, John Barja-Ore, Frank Mayta-Tovalino

Research output: Contribution to journalArticlepeer-review


Aim: To evaluate the antibacterial efficacy of desensitizing dentifrices. Material and methods: An experimental, in vitro, longitudinal, analytical, and prospective study was carried out. Subsequently, the following groups were formed: Streptococcus mutans vs Vitis® Sensible. S. mutans vs Sensodyne® Repair and Protect. Also, S. mutans vs Colgate® Sensitive Pro-ReliefTM and S. mutans vs Colgate Total 12® at 100, 50, 25, and 12.5%. Each Petri dish was properly labeled with the letter corresponding to the toothpaste and was placed in the incubator for 24 hours at 37°C. A 0.12% chlorhexidine solution was used as a positive control and distilled water as a negative control. The manuscript was written following the checklist for reporting in vitro studies (CRIS) guidelines. Results: It was found that when comparing the inhibition halos of the desensitizing toothpaste against S. mutans, Colgate® Sensitive Pro-ReliefTM 100% paste had the highest efficacy at 24 and 48 hours with an average of 25.2 ± 1.0 and 23.5 ± 1.1 mm, respectively. On the other way, Sensodyne paste had no efficacy at any of its concentrations 100, 50, 25, and 12.5%. Finally, it was found that there were statistically significant differences between each of the groups evaluated with a p < 0.001. Conclusions: It was concluded that mainly the 100% pure concentrations of the desensitizing pastes had antibacterial efficacy against S. mutans. However, Sensodyne® Repair and Protect paste had no effect. Clinical significance: This research has clinical relevance because the use of desensitizing pastes is highly frequent. Therefore, it is necessary to know if these pastes offer an efficient antibacterial effect to control the main microorganisms of the oral cavity.

Original languageEnglish
Pages (from-to)669-673
Number of pages5
JournalJournal of Contemporary Dental Practice
Issue number7
StatePublished - Jul 2022


  • Antibacterial efficacy
  • Desensitizing dentifrices
  • In vitro study


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