TY - JOUR
T1 - Anorganic Bovine Bone Plus Recombinant Human Platelet-Derived Growth Factor-BB in Ridge Preservation
T2 - A Pilot Study
AU - Mendoza-Azpur, Gerardo
AU - Cornejo, Heydi
AU - Olaechea, Allinson
AU - Padial-Molina, Miguel
AU - O’Valle, Francisco
AU - Galindo-Moreno, Pablo
N1 - Publisher Copyright:
© 2022
PY - 2022
Y1 - 2022
N2 - Purpose: To determine clinical parameters, histologic features, and radiographic linear bone width changes of regenerated bone using different biomaterials for ridge preservation following tooth extraction. Materials and Methods: For this pilot study, five patients were grafted with anorganic bovine bone and collagen plus recombinant human platelet–derived growth factor-BB (rhPDGF-BB), five patients were grafted with anorganic bovine bone and collagen alone, and five patients did not receive any biomaterial (control) after tooth extraction. Clinical, histologic, and radiographic evaluations were carried out 4 months postextraction. Results: Differences in terms of buccolingual width were found when comparing the control group to the group grafted with anorganic bovine bone and collagen plus rhPDGF-BB (P= .012). No statistical differences were observed between the groups in terms of mineralized or nonmineralized tissue formation or in terms of the number of osteoblasts or osteocytes per mm after 4 months of healing. Interestingly, the number of vessels in the grafted area was found to be significantly different among the three groups (P= .005). The number of Musashi-1 positive cells was also different among groups, both in the mineralized and the nonmineralized areas of the grafted bone (P= .024 and .005, respectively). Conclusion: Anorganic bovine bone with bovine collagen is an efficient biomaterial to avoid postextraction resorption of the alveolar ridge. The addition of rhPDGF-BB appears to improve the biologic features of the newly formed bone and decrease bone resorption; further studies are needed for confirmation. Int J Oral Maxillofac Implants 2022;37:356–364. doi: 10.11607/jomi.9022
AB - Purpose: To determine clinical parameters, histologic features, and radiographic linear bone width changes of regenerated bone using different biomaterials for ridge preservation following tooth extraction. Materials and Methods: For this pilot study, five patients were grafted with anorganic bovine bone and collagen plus recombinant human platelet–derived growth factor-BB (rhPDGF-BB), five patients were grafted with anorganic bovine bone and collagen alone, and five patients did not receive any biomaterial (control) after tooth extraction. Clinical, histologic, and radiographic evaluations were carried out 4 months postextraction. Results: Differences in terms of buccolingual width were found when comparing the control group to the group grafted with anorganic bovine bone and collagen plus rhPDGF-BB (P= .012). No statistical differences were observed between the groups in terms of mineralized or nonmineralized tissue formation or in terms of the number of osteoblasts or osteocytes per mm after 4 months of healing. Interestingly, the number of vessels in the grafted area was found to be significantly different among the three groups (P= .005). The number of Musashi-1 positive cells was also different among groups, both in the mineralized and the nonmineralized areas of the grafted bone (P= .024 and .005, respectively). Conclusion: Anorganic bovine bone with bovine collagen is an efficient biomaterial to avoid postextraction resorption of the alveolar ridge. The addition of rhPDGF-BB appears to improve the biologic features of the newly formed bone and decrease bone resorption; further studies are needed for confirmation. Int J Oral Maxillofac Implants 2022;37:356–364. doi: 10.11607/jomi.9022
KW - anorganic bovine bone
KW - rhPDGF-BB
KW - ridge preservation
UR - http://www.scopus.com/inward/record.url?scp=85128924700&partnerID=8YFLogxK
U2 - 10.11607/jomi.9022
DO - 10.11607/jomi.9022
M3 - Artículo
C2 - 35476865
AN - SCOPUS:85128924700
SN - 0882-2786
VL - 37
SP - 356
EP - 364
JO - International Journal of Oral and Maxillofacial Implants
JF - International Journal of Oral and Maxillofacial Implants
IS - 2
ER -