Aetiology, Epidemiology and clinical characteristics of acute moderate-to-severe diarrhoea in children under 5 years of age hospitalized in a referral paediatric hospital in Rabat, Morocco

Rachid Benmessaoud, Imane Jroundi, Cinta Moraleda, Miriam J. Alvarez-Martínez, Maria J. Pons, Saad Chaacho, Edward B. Hayes, Jordi Vila, Pedro L. Alonso, Quique Bassat, Joaquim Ruiz, Mouane Nezha, Houssain Tligui, Myriam Seffar

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15 Scopus citations

Abstract

The objective of the study was to describe the aetiology, epidemiology and clinical characteristics of the principal causes of acute infectious diarrhoea requiring hospitalization among children under 5 years of age in Rabat, Morocco. A prospective study was conducted from March 2011 to March 2012, designed to describe the main pathogens causing diarrhoea in hospitalized children.2 months and less than 5 years of age. Among the 122 children included in the study, enteroaggregative Escherichia coli (EAEC) and rotavirus were the main aetiological causes of diarrhoea detected. Twelve (9.8%) children were referred to an intensive care unit, while two, presenting infection by EAEC, and EAEC plus Shigella sonnei, developed a haemolytic uraemic syndrome. Additionally, six (4.9%) deaths occurred, with EAEC being isolated in four of these cases. Diarrhoeagenic E. coli and rotavirus play a significant role as the two main causes of severe diarrhoea, while other pathogens, such as norovirus and parasites, seem to have a minimal contribution. Surveillance and prevention programmes to facilitate early recognition and improved management of potentially life-threatening diarrhoea episodes are needed.

Original languageEnglish
Pages (from-to)84-92
Number of pages9
JournalJournal of Medical Microbiology
Volume64
Issue number1
DOIs
StatePublished - 1 Jan 2015

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