TY - JOUR
T1 - Acute severe hepatitis of unknown etiology in children
T2 - A mini-review
AU - Frediansyah, Andri
AU - Sallam, Malik
AU - Sallam, Malik
AU - Sallam, Malik
AU - Yufika, Amanda
AU - Sharun, Khan
AU - Iqhrammullah, Muhammad
AU - Chandran, Deepak
AU - Mamada, Sukamto S.
AU - Sallam, Dina E.
AU - Khader, Yousef
AU - Lemu, Yohannes K.
AU - Yusuf, Fauzi
AU - Kretchy, James Paul
AU - Abdeen, Ziad
AU - Torres-Roman, J. Smith
AU - Acharya, Yogesh
AU - Bondarenko, Anastasia
AU - Ikram, Aamer
AU - Jamil, Kurnia F.
AU - Kotfis, Katarzyna
AU - Koyanagi, Ai
AU - Smith, Lee
AU - Megawati, Dewi
AU - Megawati, Dewi
AU - Rademaker, Marius
AU - Emran, Talha B.
AU - Memish, Ziad A.
AU - Memish, Ziad A.
AU - Vento, Sandro
AU - Nainu, Firzan
AU - Harapan, Harapan
N1 - Publisher Copyright:
© 2022, School of Medicine, Universitas Syiah Kuala. All rights reserved.
PY - 2022/8
Y1 - 2022/8
N2 - The emergence of acute, severe non hepA–E hepatitis of unknown etiology (ASHUE) has attracted global concern owing to the very young age of the patients and its unknown etiology. Although this condition has been linked to several possible causes, including viral infection, drugs and/or toxin exposure, the exact cause remains unknown; this makes treatment recommendation very difficult. In this review, we summarize recent updates on the clinical manifestations, complemented with laboratory results, case numbers with the global distribution and other epidemiological characteristics, and the possible etiologies. We also provide the proposed actions that could be undertaken to control and prevent further spread of this hepatitis. Since many etiological and pathological aspects of the acute non hepA-E hepatitis remain unclear, further research is needed to minimize the severe impact of this disease.
AB - The emergence of acute, severe non hepA–E hepatitis of unknown etiology (ASHUE) has attracted global concern owing to the very young age of the patients and its unknown etiology. Although this condition has been linked to several possible causes, including viral infection, drugs and/or toxin exposure, the exact cause remains unknown; this makes treatment recommendation very difficult. In this review, we summarize recent updates on the clinical manifestations, complemented with laboratory results, case numbers with the global distribution and other epidemiological characteristics, and the possible etiologies. We also provide the proposed actions that could be undertaken to control and prevent further spread of this hepatitis. Since many etiological and pathological aspects of the acute non hepA-E hepatitis remain unclear, further research is needed to minimize the severe impact of this disease.
KW - Acute non hepA–E hepatitis
KW - clinical manifestations
KW - epidemiological characteristics
KW - outbreak
KW - prevention
UR - http://www.scopus.com/inward/record.url?scp=85145942835&partnerID=8YFLogxK
U2 - 10.52225/narra.v2i2.83
DO - 10.52225/narra.v2i2.83
M3 - Artículo de revisión
AN - SCOPUS:85145942835
SN - 2807-2618
VL - 2
JO - Narra J
JF - Narra J
IS - 2
M1 - e83
ER -