TY - JOUR
T1 - A meta-analysis and mapping of global mpox infection among children and adolescents
AU - Suvvari, Tarun Kumar
AU - Sandeep, Mokanpally
AU - Kumar, Jogender
AU - Satapathy, Prakasini
AU - Chenchula, Santenna
AU - Gandhi, Aravind P.
AU - Shamim, Muhammad Aaqib
AU - Schlagenhauf, Patricia
AU - Rodríguez-Morales, Alfonso J.
AU - Sah, Ranjit
AU - Pradhan, Keerti Bhusan
AU - Rustagi, Sarvesh
AU - Hermis, Alaa Hamza
AU - Padhi, Bijaya K.
N1 - Publisher Copyright:
© 2023 John Wiley & Sons Ltd.
PY - 2023/9
Y1 - 2023/9
N2 - Monkeypox (mpox) is a significant health concern affecting children and adolescents globally. This systematic review and meta-analysis aims to synthesise the available evidence on the proportion of children and adolescents affected by the mpox virus. A comprehensive search was conducted in seven electronic databases (PubMed, Scopus, Web of Science, EMBASE, ProQuest, EBSCOHost, and Cochrane) to identify the original reports on mpox cases in children and adolescents till 15 January 2023. Descriptive reports on probable or laboratory-confirmed mpox in children and adolescents (0–17 years old) were considered eligible. Studies not providing separate data for the above age group and case-control studies were excluded. The primary outcome was pooled proportion of mpox cases among children and adolescents. Proportion meta-analysis and heterogeneity between studies were determined using a restricted maximum likelihood estimator, and a random-effects model was fitted to the data. Sensitivity analysis and subgroup analysis were also conducted. A drapery plot was also provided as a complementary figure to the forest plot. The protocol was prospectively registered with PROSPERO (CRD42023392475). A total of 440 studies were identified, of which 37 were included in the review and 25 in the meta-analysis (62,701 participants with 3306 children and adolescents). The pooled proportion of children and adolescents was 0.46 (95% CI: 0.30–0.63, I2:100%). The proportion of children and adolescents was significantly lower (p < 0.001) in the ongoing pandemic 0.04 (95% CI: 0.00–0.32) than before 2022 0.62 (95% CI: 0.49–0.74). The meta-regression showed that the higher the study's sample size, the lower the proportion of children among the mpox cases. Both overall and subgroup heterogeneity were high. Adolescents and children below 5 years are commonly affected by the ongoing pandemic. In conclusion, the high proportion of children affected by the mpox virus highlights the need for increased research and targeted interventions to prevent and control the spread of the virus in this population.
AB - Monkeypox (mpox) is a significant health concern affecting children and adolescents globally. This systematic review and meta-analysis aims to synthesise the available evidence on the proportion of children and adolescents affected by the mpox virus. A comprehensive search was conducted in seven electronic databases (PubMed, Scopus, Web of Science, EMBASE, ProQuest, EBSCOHost, and Cochrane) to identify the original reports on mpox cases in children and adolescents till 15 January 2023. Descriptive reports on probable or laboratory-confirmed mpox in children and adolescents (0–17 years old) were considered eligible. Studies not providing separate data for the above age group and case-control studies were excluded. The primary outcome was pooled proportion of mpox cases among children and adolescents. Proportion meta-analysis and heterogeneity between studies were determined using a restricted maximum likelihood estimator, and a random-effects model was fitted to the data. Sensitivity analysis and subgroup analysis were also conducted. A drapery plot was also provided as a complementary figure to the forest plot. The protocol was prospectively registered with PROSPERO (CRD42023392475). A total of 440 studies were identified, of which 37 were included in the review and 25 in the meta-analysis (62,701 participants with 3306 children and adolescents). The pooled proportion of children and adolescents was 0.46 (95% CI: 0.30–0.63, I2:100%). The proportion of children and adolescents was significantly lower (p < 0.001) in the ongoing pandemic 0.04 (95% CI: 0.00–0.32) than before 2022 0.62 (95% CI: 0.49–0.74). The meta-regression showed that the higher the study's sample size, the lower the proportion of children among the mpox cases. Both overall and subgroup heterogeneity were high. Adolescents and children below 5 years are commonly affected by the ongoing pandemic. In conclusion, the high proportion of children affected by the mpox virus highlights the need for increased research and targeted interventions to prevent and control the spread of the virus in this population.
KW - children and adolescents
KW - monkeypox virus
KW - mpox
UR - http://www.scopus.com/inward/record.url?scp=85166583837&partnerID=8YFLogxK
U2 - 10.1002/rmv.2472
DO - 10.1002/rmv.2472
M3 - Artículo de revisión
C2 - 37529964
AN - SCOPUS:85166583837
SN - 1052-9276
VL - 33
JO - Reviews in Medical Virology
JF - Reviews in Medical Virology
IS - 5
M1 - e2472
ER -
