A double mutation in the gyrA gene is necessary to produce high levels of resistance to moxifloxacin in Campylobacter spp. clinical isolates

Joaquim Ruiz, Asunción Moreno, M. Teresa Jimenez De Anta, Jordi Vila

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

The aim of this study was to compare different fluoroquinolones against Campylobacter spp., analysing the molecular mechanisms of resistance. Moxifloxacin exhibited the greatest activity of the quinolones tested, being active against isolates carrying a single mutation in the gyrA gene. High resistance levels to moxifloxacin were related to the presence of a double gyrA mutation.

Original languageEnglish
Pages (from-to)542-545
Number of pages4
JournalInternational Journal of Antimicrobial Agents
Volume25
Issue number6
DOIs
StatePublished - Jun 2005

Keywords

  • Campylobacter
  • Levofloxacin
  • Moxifloxacin
  • Resistance
  • gyrA

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